Promethazine and daridorexant both equally enhance sedation. Modify Therapy/Monitor Closely. Coadministration boosts chance of CNS despair, which can lead to additive impairment of psychomotor efficiency and result in daytime impairment. benzhydrocodone/acetaminophen and codeine equally maximize sedation. Steer clear of or Use Alternate Drug. Restrict use to patients for whom choice https://wockusa.com/product/2-fdck/