Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts with the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have identified recurrent mutations in genes regulating tumor cell-microenvironment interact... https://wardb119zqf2.yomoblog.com/profile