Contraindicated (1)pentobarbital will reduce the level or result of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is responsible for the development and elimination of cariprazine's active metabolites. pentobarbital will reduce the extent or influence of theophylline by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution... https://christians592lpu1.mybuzzblog.com/profile